Is there a good to leave a computer on all the time?

The RAM purge is the biggest reason for me shutting mine down. I also don't want to sleep to fan hum (my computer is right under my bed and right under my head!) Plus the case lighting is too bright to sleep with it on.
 
i leave my pc on 24/7. other than maintenance restarts the only time i shut it down is when internet goes out.

my old p4 build (with a cheap ecs mobo) was on for 4 years straight. the maxtor hd, sony dvd rom, and an nec cdr gave out.
 
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