Hard Drive compatible with my motherboard?

So as an example, this one would work fine right?
http://www.newegg.com/Product/Product.asp?Item=N82E16822144102

Why I buy so small? Well, I have an external 500gb; I am planning to run the native OS and just programs on the internal one (in the link) and the external is used for all my other stuff.

Does anyone know or can tell me if this is efficient? Any downsides or anything?
I have a core 2 duo with 2gb dual channel ddr2667. Thanks.
 
Yes, that drive will work fine. It's more than big enough for windows and some programs. It will run out of space if you are installing a bunch of games on it though.
 
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